Metformin
- TRADE NAME: Apo-Metformin; Avandamet (GSK); Diabex; Diaformin; Diformin; Fortamet (Andrx); Gen-Metformin; Glucomet; Glucophage (Merck Serono); Glucovance (Merck Serono); Janumet (Merck Sharpe & Dohme); Metaglip; Metforal; Metomin; Novo-Metformin; Riomet
- INDICATIONS: Diabetes
- CLASS: Biguanide, Antidiabetic
- HALF-LIFE: 6 hours
ACE inhibitors, Acetazolamide, Alcohol, Amiloride, Anabolic steroids, Beta blockers, Calcium channel blockers, Captopril, Cephalexin, Cilazapril, Cimetidine, Corticosteroids, Diazoxide, Dichlorphenamide, Digoxin, Disopyramide, Diuretics, Enalapril, Estrogens, Fosinopril, Garlic, Iodinated contrast agents, Isoniazid, Ketotifen, Lanreotide, Lisinopril, Luteinizing hormone releasing hormone analogs, MAO inhibitors, Morphine, Nicotinic acid, Octreotide, Oral Contraceptives, Pegvisomant, Phenothiazines, Phenytoin, Procainamide, Progestogens, Quinapril, Quinidine, Quinine, Ramipril, Ranitidine, Somatropin, Sympathomimetics, Testosterone, Thiazides, Thyroid products, Topiramate, Trandolapril, Triamterene, Trimethoprim, Trospium, Vancomycin, Zonisamide
PREGNANCY CATEGORY: B
Lactic acidosis is a rare, but serious, metabolic complication that can occur due to metformin accumulation.
Safety and effectiveness in pediatric patients <10 years of age have not been established.
Glucovance is metformin and glyburide; Avandamet is metformin and rosiglitazone; Janumet is metformin and sitagliptin.
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Incidence 
- <1%
- 1-5%
- 5-10%
- 10-15%
- 15-20%
- 20-30%
- >30%
Seriousness
- Hospitalization possible
- Life Threatening
- Fatal
Warnings in other populations
- Breast feeding
- Geriatric
- Pediatric